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CTC Tech for Outgoing Samples & Data Sets
TECHNOLOGY: The standard right angle cannula used during cardiac
surgery requires the technical expertise and skill of multiple individuals and
is associated with significantly greater blood loss. Further, it has limited
application during surgical approaches conducted via minimally sized incisions
or alternative incisions (e.g., thoracotomy)....
Published: 12/11/2012
Category(s): Diagnostics
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Personalized Opioid Analgesia in Pediatric Patients with Acute/Surgical Pain
PERSONALIZING PAIN MANAGEMENT WITH OPIOIDS
CHMC
Ref. id. 2010-0914 and 2012-0506
Overview:
In the US alone, each year >5 million children (and >25
million adults) undergo painful surgery. Inadequate pain relief and serious side
effects from perioperative opioids occur frequently in up to 50% of children.
Several deaths and serious adverse...
Published: 12/4/2012
Category(s): Diagnostics
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SapC-DOPS Agents in Imaging Arthritis
(CHMC Ref. Id: 2011-0503)
Overview:
Rheumatoid arthritis (RA) is a chronic inflammatory disease
that affects about 1% of the population and is characterized by the destruction
of cartilage and bone ultimately leading to loss of joint function. To date,
reliable and non-invasive techniques that accurately measure arthritic disease
onset and progression...
Published: 12/4/2012
Category(s): Diagnostics
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Simultaneous ASL/BOLD Functional MRI Contrast in the Whole Brain
Simultaneous ASL/BOLD
Functional MRI Contrast in the Whole Brain
(CHMC Ref. Id: 2010-0402)
Overview:
The technology is a method for collecting whole brain alternating ASL/BOLD
fMRI images. Images were collected at 3.0 T using a PCASL technique. The
advantage compared to two separate acquisitions is that it is easier to tease
apart CBF and non-CBF...
Published: 12/4/2012
Category(s): Diagnostics
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Diagnostic for Lupus Nephritis
Diagnostic for Lupus Nephritis
(CHMC Ref. Id: 2007-0609)
Overview:
Lupus nephritis is an inflammation of the kidney caused by systemic lupus
erythematosus (SLE), a disease of the immune system. Patients suffering from
lupus nephritis may experience weight gain, high blood pressure, dark urine, or
swelling around the eyes, legs, ankles, or fingers....
Published: 12/4/2012
Category(s): Diagnostics
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Serum Biomarker for Stratifying Patients in Septic Shock Clinical Trials
Overview:
Currently,
there exists no method for stratifying pediatric septic shock clinical trial
candidates. Specifically, there is no way to eliminate patients that would have
a high likelihood of a positive outcome with standard care from these trials.
Dr. Wong at Cincinnati Children's Hospital has demonstrated that there is a
marked increase...
Published: 12/12/2012
Category(s): Diagnostics
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Diagnostic and Prognostic for Crohn's Disease and Ulcerative Colitis
Diagnostic and Prognostic for
Crohn's Disease and Ulcerative Colitis
(CHMC Ref. Id: 2007-0105)
Overview:
Several defects in neutrophil function have been noted in Crohn's Disease
(CD), including reduced phagocytosis, adhesion, chemotaxis, and oxidative burst.
This has been shown to reduce neutrophil accumulation at sites of injury,
promoting the...
Published: 12/12/2012
Category(s): Diagnostics
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Diagnostic and Prognostic for Crohn's Disease
Diagnostic and Prognostic for
Crohn's Disease
(CHMC Ref. Id: 2006-0202)
Overview:
Standard therapies for IBD include steroids and immunomodulators which lead
to a sustained remission in approximately 50% of patients. Currently, there are
no reliable predictors of response, leading Dr. Denson and colleagues to prepare
and stratify patient samples...
Published: 12/4/2012
Category(s): Diagnostics
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Gene Expression Signature Profiles for Stable and Acute Asthma
Gene Expression Signature
Profiles for Stable and Acute Asthma
(CHMC Ref. Id: 2005-0601)
Overview:
Asthma is the most common chronic disease of childhood and has a genetic
component. Microassay technology has been used to identify gene profiles
associated with asthma but were limited to adults and to RNA derived from
peripheral blood mononuclear...
Published: 12/4/2012
Category(s): Diagnostics
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Diagnostic Classification of Esophagitis
Diagnostic Classificiation of
Esophagitis
(CHMC Ref. Id: 2005-0401)
Overview:
Eosinophilic esophagitis (EoE) is an emerging worldwide disease and growing
health problem. The primary symptoms of EoE (chest and abdominal pain,
dysphagia, heartburn, vomiting, and food impaction) are also observed in
patients with chronic esophagitis (CE), including...
Published: 12/4/2012
Category(s): Diagnostics
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