Center For Technology Commercialization

Simultaneous ASL/BOLD Functional MRI Contrast in the Whole Brain

(CHMC Ref. Id: 2010-0402)

Overview:

The technology is a method for collecting whole brain alternating ASL/BOLD fMRI images. Images were collected at 3.0 T using a PCASL technique. The advantage compared to two separate acquisitions is that it is easier to tease apart CBF and non-CBF related contribution to the BOLD signal because inter-scan variability is not present. In addition, efficient timing of the stimulus permits ASL and BOLD maps with good contrast-to-noise ratios to be obtained in under 10 minutes. Robust functional contrast for both BOLD and ASL was shown for an adult subject performing a narrative comprehension task. However, there was not complete overlap between regions with ASL and regions with BOLD contrast. This is likely related to regional differences in the CMRO2 changes and neuronal-vascular coupling.

Applications:

• Simultaneous collection of ASL and BOLD functional MRI contrast
• Collection of whole brain images

Advantages:

• Easier separation of CBF and non-CBF related contributions to BOLD signal
• Less inter-scan variability
• Shorter scan times
• Good contrast-to-noise ratios

Patent Information:

• Patent Applications Pending

Cincinnati Children's Lead Inventor:

Scott K. Holland, Ph.D.